![]() If supervision isn't adequate warfarin poses a threat in causing, all too frequent, haemorrhagic events and multiple interactions with food and other drugs. Warfarin treatment requires blood monitoring and dose adjustments regularly due to its narrow therapeutic window. ![]() It wasn't until 1954 that it was approved for medicinal use in humans making warfarin the first oral anticoagulant drug. ![]() He and his colleagues worked on several variations and ended up with a substance they named warfarin in 1948. They patented the right for the substance and in 1945 Link started selling a coumarin derivative as a rodenticide. It took them 6 years to discover dicoumarol, the causing agent. Link and his student Wilhelm Schoeffel started an intense investigation to find the substance causing the internal bleeding. It wasn't until ten years after the outbreak, that a local investigator, Karl P. ![]() The disease was named sweet clover disease because the cattle had grazed on sweet clover hay. In the 1920s there was an outbreak of a mysterious haemorrhagic cattle disease in Canada and the northern United States. ![]()
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